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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH6
All Species:
22.12
Human Site:
Y1128
Identified Species:
34.76
UniProt:
P52701
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52701
NP_000170.1
1360
152786
Y1128
E
Q
E
N
G
K
A
Y
C
V
L
V
T
G
P
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001113749
1360
152750
Y1128
E
Q
E
N
G
K
A
Y
C
V
L
V
T
G
P
Dog
Lupus familis
XP_531814
1283
145094
A1074
M
R
Q
A
G
L
L
A
V
M
A
Q
M
G
C
Cat
Felis silvestris
Mouse
Mus musculus
P54276
1358
151058
Y1126
A
E
E
H
G
K
A
Y
C
V
L
V
T
G
P
Rat
Rattus norvegicus
XP_002726765
1361
151628
Y1129
A
E
A
D
G
K
A
Y
C
V
L
V
T
G
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419359
1466
164165
S1234
E
D
G
G
S
E
A
S
C
V
L
V
T
G
P
Frog
Xenopus laevis
NP_001089247
1340
149481
H1110
D
D
G
S
D
E
A
H
C
V
L
V
T
G
P
Zebra Danio
Brachydanio rerio
NP_878280
1369
153213
P1137
D
D
T
K
A
L
A
P
C
V
L
V
T
G
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUM0
1190
133117
I984
M
A
Q
I
G
A
H
I
P
A
A
S
C
R
L
Honey Bee
Apis mellifera
XP_392346
1120
127429
R914
G
G
K
S
T
L
M
R
Q
V
A
L
L
T
I
Nematode Worm
Caenorhab. elegans
NP_491163
1186
133609
I980
R
Q
T
A
V
L
A
I
L
A
H
I
G
S
M
Sea Urchin
Strong. purpuratus
XP_797647
1335
149141
S1104
D
G
N
H
G
N
S
S
C
I
L
V
T
G
P
Poplar Tree
Populus trichocarpa
XP_002320307
1288
142120
R1078
F
E
L
S
P
V
D
R
I
F
V
R
M
G
A
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04716
1324
146779
S1077
I
G
G
A
E
K
A
S
F
I
L
L
T
G
P
Baker's Yeast
Sacchar. cerevisiae
Q03834
1242
140062
S1036
D
N
I
M
Q
G
K
S
T
F
F
V
E
L
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
88.1
N.A.
85.8
86.4
N.A.
N.A.
64.2
66.5
60
N.A.
39
41.2
34.4
48.6
Protein Similarity:
100
N.A.
98.6
91.3
N.A.
92.1
92.8
N.A.
N.A.
75.4
79.9
74.9
N.A.
57.6
58
52.7
66.6
P-Site Identity:
100
N.A.
100
13.3
N.A.
80
73.3
N.A.
N.A.
60
53.3
53.3
N.A.
6.6
6.6
13.3
46.6
P-Site Similarity:
100
N.A.
100
33.3
N.A.
93.3
86.6
N.A.
N.A.
66.6
80
60
N.A.
13.3
26.6
20
73.3
Percent
Protein Identity:
36.1
N.A.
N.A.
33.2
29
N.A.
Protein Similarity:
52
N.A.
N.A.
51.4
49.1
N.A.
P-Site Identity:
6.6
N.A.
N.A.
40
6.6
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
53.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
14
7
7
20
7
7
60
7
0
14
20
0
0
0
14
% A
% Cys:
0
0
0
0
0
0
0
0
54
0
0
0
7
0
7
% C
% Asp:
27
20
0
7
7
0
7
0
0
0
0
0
0
0
0
% D
% Glu:
20
20
20
0
7
14
0
0
0
0
0
0
7
0
0
% E
% Phe:
7
0
0
0
0
0
0
0
7
14
7
0
0
0
0
% F
% Gly:
7
20
20
7
47
7
0
0
0
0
0
0
7
74
0
% G
% His:
0
0
0
14
0
0
7
7
0
0
7
0
0
0
0
% H
% Ile:
7
0
7
7
0
0
0
14
7
14
0
7
0
0
7
% I
% Lys:
0
0
7
7
0
34
7
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
7
0
0
27
7
0
7
0
60
14
7
7
7
% L
% Met:
14
0
0
7
0
0
7
0
0
7
0
0
14
0
7
% M
% Asn:
0
7
7
14
0
7
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
7
0
0
7
7
0
0
0
0
0
60
% P
% Gln:
0
20
14
0
7
0
0
0
7
0
0
7
0
0
0
% Q
% Arg:
7
7
0
0
0
0
0
14
0
0
0
7
0
7
0
% R
% Ser:
0
0
0
20
7
0
7
27
0
0
0
7
0
7
0
% S
% Thr:
0
0
14
0
7
0
0
0
7
0
0
0
60
7
0
% T
% Val:
0
0
0
0
7
7
0
0
7
54
7
60
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
27
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _